Antifungal Therapeutic Drug Monitoring: Established and Emerging Indications

Antifungal therapeutic drug monitoring: established and emerging indications.

Andres Pascual Dept of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH-1011 Lausanne, Switzerland [email protected] 41 21 314 0909 AC CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00705-08 AAC Accepts, published online ahead of print on...

[Therapeutic drug monitoring of antifungal agents].

Antifungal therapeutic drug monitoring: when, how, and why.

In recent years, the incidence of invasive fungal infections (IFI) has risen in parallel with a growing population of patients immunosuppressed as a consequence of different conditions, such as HIV infection, increasingly aggressive surgical techniques, solid organ and hematopoietic transplantations, illness severity of critically ill patients and, in a lower rate, anti-TNF therapies.1–3 In spi...

therapeutic drug monitoring

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Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications

SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the clinical relevance of ROS is still largely unclear. RECENT ADVANCES We are now beginning to understand the reasons for these failures, which re...